Your Instructors
Dr Olivia Ly Lesslar, MBBS
Dr Lesslar, MBBS (Bachelor of Medicine, Bachelor of Surgery — equivalent to MD) is an Australian medical doctor specialising in psychoneuroimmunology and longevity medicine. Known as a “medical Sherlock Holmes,” she is recognised for her investigative approach to diagnosing and managing complex, multi-systemic conditions that challenge conventional frameworks. Dr Lesslar is the Director of Functional and Longevity Medicine at Cingulum Health in Sydney, where she integrates neuroplastic therapies and transcranial magnetic stimulation with functional medicine for neurological and psychiatric care. She also serves in leadership and advisory roles across more than thirty international organisations spanning neurotechnology, biotechnology, and space medicine, including Human Regenerator (UK), L’evive Labs (Singapore), Sens.ai (Canada), ANI Biome (Croatia), and Oxford Healthspan (UK). Dr Lesslar holds academic appointments at Griffith University’s NCNED and the Geneva College of Longevity Science. Her research and teaching focus on advancing integrative, patient-centred models of care that unite neuroscience, immunology, and behavioural science.
Dr Sandeep Gupta, MBBS
Dr Gupta, MBBS (Bachelor of Medicine, Bachelor of Surgery — equivalent to MD) is a vocationally registered general practitioner who runs Lotus Holistic Medicine, an integrative medicine clinic on the Sunshine Coast, Australia. His main passion relates to finding the underlying causes and innovated approaches to managing chronic illness. After graduating from medical school at the University of Queensland in Australia in 1999 he worked in the hospital system for ten years before a brush with illness led him to embracing a more holistic model of patient care. His initial approach was heavily dietary and nutritionally oriented but later he came to know of environmentally related illnesses such as mold-related illness, tick-borne disease and heavy metal toxicity. He has now treated over 10,000 patients with environmental illnesses such as these and is passionate to share his knowledge with other practitioners keen to add his tools and tips to their tool kit. In 2017 he established the Lotus Institute of Holistic Health which in addition to Mast Cells Made Simple has launched the online courses Mold Illness Made Simple, EMFs Made Simple and in 2026 the practitioner-focused Mold Illness Mastery.
6 ¼ hours of Video Lectures
- Introduction (4 min)
- Introduction to Mast Cells Made Simple & Dr Lesslar
- Module 1 – Introduction to Mast Cells (55 min)
- L1: What Are Mast Cells?
- L2: Role of Mast Cells in the Immune System
- Module 2 – Mast Cell Activation and Its Triggers (40 min)
- L1: Overview of Mast Cell Activation
- L2: Types of Mast Cell Activators (Molecular and Celluar Pathways)
- L3: Common Triggers
- Module 3 – Mast Cell Disorders: An Overview (1 hour)
- L1: Mast Cell Disorders (Overview)
- L2: MCAS vs Histamine Intolerance
- L3: MCAS vs. Allergies and Sensitivities
- L4: The Pentad Super Syndrome
- Module 4 – Diagnosing Mast Cell Disorders (30 min)
- L1: Clinical Evaluation and Patient History
- L2: Laboratory Tests and Biomarkers
- L3: Differential Diagnosis
- Module 5 – Management and Treatment Strategies (44 min)
- L1: Pharmacological Treatments
- L2: Lifestyle and Environmental Modifications, Female Hormones
- L3: Complementary and Emerging Therapies
- Module 6 – Root Causes and Emerging Drivers (50 min)
- L1: Environmental and Toxic Drivers (incl. Mold, Metals, Chemicals)
- L2: Hidden Influences (EMFs, Emotional Trauma and Psychological Stress)
- L3: Biological Triggers (Stealth Infections/Lyme, Microbiome)
- Module 7 – Living With MCAS (51 min)
- L1: Navigating Daily Life with MCAS
- L2: Patient Advocacy and Support Networks
- Module 8 – Future Directions and Integrative Perspectivies (43 min)
- L1: Mast Cells and Mental Health
- L2: New Research and Evolving Conventional Therapies
- L3: Biohacks and Other Therapies
Video lectures by instructors Dr Olivia Lesslar, MBBS & Dr Sandeep Gupta, MBBS
Slides that can be downloaded in PDF format
14-day money back guarantee (subject to T&Cs)
Compatibility across desktop, laptop, tablet and smartphone devices
Australian physician Dr Olivia Lesslar, MBBS (a medical “Sherlock Holmes”) is the main instructor for Mast Cells Made Simple.
Dr Sandeep Gupta, MBBS is a guest instructor for module 6 on the environmental and toxic drivers of MCAS including mold, heavy metals and man-made chemicals.
Mast cell activation syndrome (MCAS) is an emerging condition that sees mast cells, a major player in the human immune system, chronically release mediators (chemicals) which causes a myriad of symptoms. MCAS goes hand-in-hand with other complex chronic illness including mold-related illness, electromagnetic hypersensitivity syndrome (EHS)/electromagnetic (EMF) sensitivity, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibromyalgia, postural orthostatic tachycardia syndrome (POTS) and more.
Dr Olivia Lesslar, MBBS will explain the role of mast cells in the immune system, what happens when they go awry, and the mechanism of MCAS. She also explains how MCAS is diagnosed and what management and treatment strategies are possible. Dr Sandeep Gupta, MBBS is a guest instructor for module 6, that details the environmental and toxic drivers of MCAS including mold, heavy metals and man-made chemicals.
Yes. The Lotus Institute is currently developing the following courses for relase in 2026/27:
- Integrative Cancer Made Simple
- Women’s Hormones Made Simple
- Weight Loss Made Simple
As of May 2026 the Lotus Institute currently has three Made Simple course currently available for enrollment:
The Made Simple courses are on-demand online courses for both health practitioners (introductory level) and the general public.